Table 8.

Cox regression analysis of clinical characteristics as influencing factors of EGFR-TKIs acquired resistance occurring for 20 cases with acquired EGFR T790M mutation.

Clinical characteristics	HR	95% CI	P value
Age	0.984	0.125–7.738	0.987
Gender	1.098	0.443–2.718	0.840
Smoking	0.791	0.297–2.105	0. 639
Clinical stage	0.922	0.243–3.501	0.905
EGFR sensitive mutation type	0.869	0.347–2.173	0.764
EGFR-TKI type	0.825	0.278–2.452	0.729
HIF-1α level	0.004	0.000–1.324	0.042

HR hazard ratio, CI confidence interval.