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. 2021 Jan 13;11:952. doi: 10.1038/s41598-020-78654-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of study findings. (A) A network of all 1707 epilepsy- and autism-associated genes from Wang et al. (2017)¹⁰ and SFARI⁶⁰ and (B) A network of 294 epilepsy and autism genes from WES studies^38,61. The edges represent the union of edges from the PPI network layer and phenotype network layer of the multiplex network. The color of a node represents the module it belongs to in the multiplex network and the size of the node is relative to its degree in the network. Key modules identified in the study are annotated. The network plots were generated using Gephi version 0.9.2, a graph visualization software. (C) The five autism-specific genes (i.e. not listed in Wang et al. (2017)¹⁰) in module 3 and 6 of the larger multiplex network that overlap with epilepsy-focused module 2 of the WES network are predicted candidate epilepsy genes.