Table 2.
Highest centrality genes in module 3.
| Top 20 genes by average degree | PPI degree | Phenotype degree | Annotation | Top 20 genes by average BC | PPI BC | Phenotype BC | Annotation |
|---|---|---|---|---|---|---|---|
| CALM2 | 32 | 139 | Epilepsy 3 | CALM2 | 0.00665306 | 0.01452167 | Epilepsy 3 |
| CACNG2 | 33 | 70 | Epilepsy 3 | AKAP9 | 0.00902041 | 0.00222203 | Autism 2 |
| AKAP9 | 47 | 53 | Autism 2 | NRCAM | 0.00154433 | 0.00815726 | Autism 3 |
| CACNA2D2 | 16 | 73 | Epilepsy 4 | KCNAB2 | 0.00673046 | 0.0024144 | Epilepsy 4 |
| CACNA1C | 35 | 49 | Autism 1 | CACNA2D2 | 0.00056149 | 0.00762001 | Epilepsy 4 |
| KCNS3 | 3 | 68 | Autism 2 | CACNG2 | 0.00262347 | 0.00493458 | Epilepsy 3 |
| CACNA2D3 | 10 | 61 | Autism 2 | CACNA1C | 0.00619087 | 0.00080327 | Autism 1 |
| KCNB1 | 5 | 66 | Epilepsy 1, Autism 1 | CACNA1A | 0.00647452 | 0.00040586 | Epilepsy 1, Autism S |
| KCNA2 | 13 | 58 | Epilepsy 1 | CNTN2 | 0.00026388 | 0.00651281 | Epilepsy 1 |
| KCND2 | 7 | 64 | Epilepsy 4, Autism 3 | GABRB1 | 4.39E−05 | 0.00625521 | Epilepsy 1 |
| GRIA2 | 32 | 38 | Autism 2 | CACNA2D3 | 7.99E−05 | 0.00614434 | Autism 2 |
| KCNAB1 | 15 | 55 | Epilepsy 4 | USH2A | 0.00175342 | 0.00408082 | Autism 3 |
| SCN3A | 9 | 60 | Epilepsy 4 | ANK3 | 0.00210367 | 0.00350903 | Epilepsy 3, Autism 1 |
| GABRA6 | 13 | 54 | Epilepsy 4 | FGF12 | 6.39E−05 | 0.0051396 | Epilepsy 1 |
| CACNA1B | 20 | 47 | Autism 3 | GPHN | 0.0046279 | 0.00043612 | Epilepsy 3, Autism 2 |
| KCNK7 | 0 | 66 | Autism 3 | HTR3A | 0.00144429 | 0.00358634 | Autism 3 |
| KCNMB3 | 3 | 62 | Epilepsy 4 | KCNB1 | 0.00017102 | 0.00484786 | Epilepsy 1, Autism 1 |
| GABRA4 | 13 | 52 | Autism 3 | CHRNA4 | 0.0037866 | 0.00120251 | Epilepsy 1 |
| CACNA1D | 22 | 41 | Epilepsy 3, Autism 2 | ACHE | 0.00277761 | 0.00141233 | Autism 2 |
| GABRG3 | 10 | 51 | Autism 2 | CACNA1E | 0.0008944 | 0.00322882 | Autism 2 |
The top 20 genes in module 3 are listed and ranked by average degree and average betweenness centrality (BC). Genes that are autism-specific are bolded since module 3 is an epilepsy-focused module.