Table 3.
Highest centrality genes in module 6.
| Top 20 genes by average degree | PPI degree | Phenotype degree | Annotation | Top 20 genes by average BC | PPI BC | Phenotype BC | Annotation |
|---|---|---|---|---|---|---|---|
| DLG4 | 75 | 87 | Autism 1 | DLG4 | 0.02611288 | 0.00199529 | Autism 1 |
| GRM5 | 47 | 49 | Autism 3 | SNAP25 | 0.01245612 | 0.00012814 | Epilepsy 4, Autism 3 |
| GRIA1 | 45 | 40 | Autism 2 | GRIA1 | 0.00943414 | 0.00236783 | Autism 2 |
| DLG3 | 37 | 19 | Epilepsy 3 | GRM5 | 0.00310818 | 0.00609329 | Autism 3 |
| SNAP25 | 46 | 7 | Epilepsy 4, Autism 3 | SHANK1 | 0.00068914 | 0.0084605 | Epilepsy 4, Autism 2 |
| NRXN2 | 25 | 27 | Autism 1 | SNRPN | 0.001995 | 0.00575377 | Epilepsy 3 |
| GRM1 | 49 | 2 | Epilepsy 3 | CHD8 | 0.00628398 | 0.00034323 | Epilepsy 3, Autism 1 |
| NRXN3 | 24 | 26 | Autism 1 | FMR1 | 0.00591127 | 0 | Epilepsy 3, Autism 1 |
| SHANK1 | 25 | 25 | Epilepsy 4, Autism 2 | DLG1 | 0.00499386 | 0.00065879 | Autism 3 |
| STXBP1 | 24 | 25 | Epilepsy 1, Autism 1 | GRIK5 | 0.00022519 | 0.0047488 | Autism 2 |
| NLGN4X | 21 | 27 | Autism 2 | GRM1 | 0.0049405 | 0 | Epilepsy 3 |
| DLGAP1 | 21 | 27 | Autism 2 | CNKSR2 | 3.16E−05 | 0.00450633 | Autism 2, Autism S |
| NLGN2 | 22 | 25 | Autism 1 | HCFC1 | 0.00444098 | 1.86E−05 | Epilepsy 3, Autism S |
| SHANK2 | 20 | 27 | Autism 1 | USP9X | 0.0038062 | 0.00032409 | Epilepsy 3, Autism S |
| NLGN1 | 22 | 24 | Epilepsy 4, Autism 2 | STX1A | 0.00388987 | 0 | Autism 3 |
| CNKSR2 | 11 | 35 | Autism 2, Autism S | STXBP1 | 0.00283952 | 0.00090111 | Epilepsy 1, Autism 1 |
| NLGN3 | 21 | 23 | Autism 1 | SYT1 | 0.00352268 | 0 | Autism S |
| DLGAP2 | 19 | 25 | Autism 3 | GDI1 | 0.00331726 | 1.86E−05 | Epilepsy 3 |
| SNRPN | 17 | 25 | Epilepsy 3 | CDKL5 | 0.00139387 | 0.00166681 | Epilepsy 1, Autism 1 |
| STX1A | 34 | 8 | Autism 3 | NLGN2 | 0.00148443 | 0.00156034 | Autism 1 |
The top 20 genes in module 6 are listed and ranked by average degree and average betweenness centrality (BC). Genes that are epilepsy-specific are bolded since module 6 is an autism-focused module.