Figure 2.

Efficient prevention of Gaucher disease in an early intervention approach

(A) Experimental design of the early intervention study. (B–D) Glucocerebroside (GlcCer) quantification in BM (B), spleen (C) and liver (D) 20 weeks posttransplant. (E) VCN was estimated in whole tissue lysates from BM, blood, spleen, and liver samples. (F) Relative spleen mass reduction (graph depicting the percentage of spleen mass: total body mass for individual mice). (G) Relative liver mass reduction (graph depicting the percentage of liver mass: total body mass for individual mice). Mock, n = 13; LV, n = 13; WT, n = 8. Mann-Whitney U-test; ∗p ≤ 0.05; ∗∗p ≤ 0.01; ∗∗∗p ≤ 0.001; ∗∗∗∗p ≤ 0.0001. Error bars represent mean ± SD.