Figure 5.

Bone pathology partially corrected by gene therapy in Gaucher mouse model

Micro-CT analysis of spine L4 vertebral body and femur metaphysis area. (A) Bone volume density (BV/TV) of L4 in male and female mice in late intervention study. L4 males; Mock, n = 8; LV, n = 6; WT, n = 4. L4 females; Mock, n = 7; LV, n = 4; WT, n = 4. (B) BV/TV in femur of male and female mice in late intervention study. Femur males; Mock, n = 6; LV, n = 5; WT, n = 4. Femur females; Mock, n = 7; LV, n = 3; WT, n = 4. Additional micro-CT information is in the Supplemental Information (Figures S5 and S6). Mann-Whitney U-test ∗p ≤ 0.05; ∗∗p ≤ 0.01; ∗∗∗p ≤ 0.001; ∗∗∗∗p ≤ 0.0001. Error bars represent mean ± SD.