Table 2.
The information of 24 IRGPs in the selected model.
| IRG 1 | Full name | IRG 2 | Full name | Coefficient |
|---|---|---|---|---|
| CREB1 | cAMP responsive element binding protein 1 | TNFSF13B | Tumor necrosis factor superfamily member 13b | 0.022 |
| HLA-DOB | Major histocompatibility complex, class II, DO beta | CETP | Cholesteryl ester transfer protein | − 0.083 |
| HLA-DQA1 | Major histocompatibility complex, class II, DQ alpha 1 | C3 | Complement C3 | − 0.061 |
| HLA-DQA1 | Major histocompatibility complex, class II, DQ alpha 1 | NR2F6 | Nuclear receptor subfamily 2 group F member 6 | − 0.025 |
| CXCL14 | C-X-C motif chemokine ligand 14 | CMTM8 | CKLF like MARVEL transmembrane domain containing 8 | 0.029 |
| CXCL11 | C-X-C motif chemokine ligand 11 | FABP7 | Fatty acid binding protein 7 | − 0.033 |
| CXCL11 | C-X-C motif chemokine ligand 11 | TUBB3 | Tubulin beta 3 class III | − 0.079 |
| CXCL13 | C-X-C motif chemokine ligand 13 | SHC4 | SHC adaptor protein 4 | − 0.001 |
| CCL13 | C–C motif chemokine ligand 13 | FABP4 | Fatty acid binding protein 4 | − 0.063 |
| CCL8 | C–C motif chemokine ligand 8 | TUBB3 | Tubulin beta 3 class III | − 0.51 |
| SLC22A17 | Solute carrier family 22 members 17 | GNAI1 | G protein subunit alpha i1 | − 0.295 |
| NOX4 | NADPH oxidase 4 | PRKCB | Protein kinase C beta | − 0.173 |
| IDO1 | Indoleamine 2,3-dioxygenase 1 | CXCR3 | C-X-C motif chemokine receptor 3 | − 0.014 |
| TNFSF10 | Tumor necrosis factor superfamily member 10 | PGF | Placental growth factor | − 0.094 |
| IRF1 | Interferon regulatory factor 1 | PPP3CB | Protein phosphatase 3 catalytic subunit beta | − 0.009 |
| ZYX | Zyxin | GPI | Glucose-6-phosphate isomerase | − 0.097 |
| ITGAV | Integrin subunit alpha V | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | − 0.049 |
| ABCC4 | ATP binding cassette subfamily C member 4 | VEGFC | Vascular endothelial growth factor C | − 0.006 |
| CDH1 | Cadherin 1 | IL6ST | Interleukin 6 signal transducer | 0.139 |
| CD72 | CD72 molecule | NR2F1 | Nuclear receptor subfamily 2 group F member 1 | − 0.122 |
| SEMA3B | Semaphorin 3B | NR2F2 | Nuclear receptor subfamily 2 group F member 2 | − 0.133 |
| SEMA3C | Semaphorin 3C | MET | MET proto-oncogene, receptor tyrosine kinase | − 0.136 |
| TNC | Tenascin C | SORT1 | Sortilin 1 | − 0.096 |
| DKK1 | Dickkopf WNT signaling pathway inhibitor 1 | ITK | IL2 inducible T-cell kinase | 0.07 |
Abbreviation: IRGPs immune related gene pairs, IRG1 immune related gene 1, IRG2 immune related gene 2.