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. 2021 Jan 13;12(1):81. doi: 10.1038/s41419-020-03369-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A–D Immunofluorescence intensity of the TF-positive (A), TFR1-positive (B), TFR2-positive (C), and FPn-positive (D) signal increased, while the TH-positive signal decreased 4 and 17 months after α-syn PFFs treatments compared to the control. Arrows show colocalization of TF, TFR1, TFR2, FPn with TH in dopaminergic neurons. Arrowheads (A) show the presence of TF in oligodendrocytes. E–H Colocalizations of TF, TFR1, TFR2, FPn, and TH increased in the substantia nigra after α-syn PFFs treatment. α-Syn, α-synuclein; TF, transferrin; TFR1, transferrin receptor 1; TFR2, transferrin receptor 2; FPn, ferroportin. The data are presented as the mean ± SEM of three independent experiments. *p < 0.05 and **p < 0.01 vs. control group, ^##p < 0.01 vs. 4-month group, one-way ANOVA. Scale bars: 25 μm in A–D.