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. 2021 Jan 13;12(1):81. doi: 10.1038/s41419-020-03369-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A Dopaminergic neurons appeared to have a normal morphology without clear degenerative alterations in different groups. B Stereological analyses of dopaminergic neurons in the substantia nigra. C–J Scattered dystrophic axonal swellings were observed in the putamen on both sides, at different time points in response to α-syn PFFs treatment. C, G In comparison, the control displays homogenous distribution with no pathological terminals. K–M Quantitative analyses of the intensity of TH immunoreactivity in the putamen (ipsilateral side: K; contralateral side: L; both sides: M). α-Syn, α-synuclein; TH, tyrosine hydroxylase. The data are presented as the mean ± SEM of three independent experiments. **p < 0.01 vs. control group, ^#p < 0.05, ^##p < 0.01 vs. 1-month group, ^ΔΔp < 0.01 vs. 4-month group, one-way ANOVA (K, L). Scale bars: 50 μm in A, C–J and 25 µm in the insets.