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. 2021 Jan 13;11:1086. doi: 10.1038/s41598-020-79927-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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OxLDL uptake and scavenger receptor expression in HSP60 KD TDMs. Knockdown of HSP60 in TDMs was confirmed by (a) quantitative RT-PCR and (b) western blotting (n = 3). **p < 0.01, vs untreated KD-Control, two-tailed Student’s t-test. TDMs were subjected to ORO staining to check the OxLDL uptake (c). Representative images of stained cells (Scale bar = 10 µm) and (d) quantitative measurement of OxLDL accumulation. mRNA expression of (e) SR-A1, (f) CD36 and (g) SR-B1 was evaluated by quantitative RT-PCR. (h) Comparative analysis of mRNA expression of the three SRs in OxLDL treated KD-Control and HSP60 KD TDMs expressed as percentage of total fold change observed in respective groups. Data were expressed as Mean ± SEM (n = 3). *p < 0.05, ***p < 0.001 vs untreated KD-Control. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs untreated HSP60 KD. ⁺p < 0.05, ⁺⁺⁺p < 0.001 KD-Control group vs HSP60 KD group, ns non-significant, Two-way ANOVA followed by Tukey’s multiple comparison test.