Table 3.
Correlates of drug-related problems estimated by multivariable logistic regression.
| Variable | Categories | OR crude (95% CI) | p | AOR (95% CI) | p |
|---|---|---|---|---|---|
| Department | Respiratory | 1.000 | – | – | – |
| Digestology | 1.003 (0.702 to 1.521) | 0.870 | – | – | |
| Geriatrics | 0.977 (0.722 to 1.321) | 0.880 | – | – | |
| Internal Medicine | 0.898 (0.674 to 1.198) | 0.465 | – | – | |
| Neurology | 0.869 (0.636 to 1.187) | 0.377 | – | – | |
| Age | 1.001 (0.995 to 1.008) | 0.747 | 0.993 (0.983 to 1.002) | 0.132 | |
| Gender | Male | 1.000 | – | 1.000 | – |
| Female | 0.870 (0.714 to 1.061) | 0.170 | 0.861 (0.689 to 1.002) | 0.164 | |
| Last-12 months HA | No | 1.000 | – | 1.000 | – |
| Yes | 1.306 (1.071 to 1.592) | 0.008 | 1.110 (0.897 to 1.373) | 0.336 | |
| Country | Spain | 1.000 | – | – | – |
| Foreigner | 0.805 (0.494 to 1.312) | 0.384 | – | – | |
| Coming from NH | No | 1.000 | – | – | – |
| Yes | 1.045 (0.739 to 1.479) | 0.802 | – | – | |
| Missing information | No | 1.000 | – | – | – |
| Yes | 1.075 (0.601 to 1.923) | 0.808 | – | – | |
| Hepatic impairment | No | 1.000 | – | – | – |
| Yes | 1.073 (0.785 to 1.467) | 0.657 | – | – | |
| Estimated 10-year survival (Charlson Index) | ≤ Median | 1.000 | – | 1.000 | – |
| > Median | 0.808 (0.643 to 1.016) | 0.069 | 0.933 (0.670 to 1.300) | 0.684 | |
| Polypharmacy | 1.052 (1.030 to 1.075) | 0.000 | 1.040 (1.010 to 1.071) | 0.009 | |
| Allergies | No | 1.000 | – | 1.000 | – |
| Yes | 1.328 (1.049 to 1.682) | 0.018 | 1.281 (1.004 to 1.634) | 0.047 | |
| BMI | 18–25 | 1.000 | – | 1.000 | – |
| < 18 | 0.936 (0.0734 to 1.195) | 0.598 | 0.949 (0.731 to 1.232) | 0.695 | |
| > 25 | 1.535 (1.173 to 2.009) | 0.002 | 1.515 (1.143 to 2.007) | 0.004 | |
| NCC | 1.088 (1.037 to 1.1142) | 0.001 | 1.037 (0.975 to 1.103) | 0.242 | |
| Renal function | ≥ 60 | 1.000 | – | 1.000 | – |
| 30–60 | 1.406 (0.650 to 3.042) | 0.386 | 1.742 (0.756 to 4.015) | 0.192 | |
| < 30 | 1.706 (1.013 to 2.874) | 0.045 | 2.146 (1.200 to 3.837 | 0.010 | |
| Interactions | |||||
| NCC*renal function | NCC* ≥ 60 | 1.000 | – | 1.000 | – |
| NCC*30–60 | 0.963 (0.871 to 1.065) | 0.468 | 0.954 (0.858 to 1.061) | 0.384 | |
| NCC* < 30 | 0.922 (0.854 to 0.996) | 0.039 | 0.908 (0.838 to 0.985) | 0.021 |
Results refer to univariate and multivariable logistic regression for the total sample. Age and polypharmacy were included as continuous variables. AOR adjusted odds ratio, BMI body mass index, CI confidence interval, HA Hospital admissions, NCC number of chronic conditions, NH nursing home, OR odds ratio.