Table 2.
Clinicopathological correlation of the percentage of pre-S2 plus pre-S1 + pre-S2 deletion in 40 HBV-related HCC patients.
| Characteristicsa | Low (no. of patients (%)) | High (no. of patients (%))b | P valuec |
|---|---|---|---|
| Density of CTLsd | 25 (100) | 15 (100) | |
| High | 13 (52) | 6 (40) | 0.1983 |
| Low | 12 (48) | 9 (60) | |
| Density of CD4+CD25+ cellse | 25 (100) | 15 (100) | |
| High | 6 (24) | 14 (93) | < 0.0001*** |
| Low | 19 (76) | 1 (7) | |
| Density of granzyme B-expressing cellsf | 25 (100) | 15 (100) | |
| High | 17 (68) | 2 (13) | 0.0009*** |
| Low | 8 (32) | 13 (83) | |
| Density of Foxp3-expressing cellsg | 25 (100) | 15 (100) | |
| High | 3 (12) | 12 (80) | < 0.0001*** |
| Low | 22 (88) | 3 (20) |
HBV hepatitis B virus, HCC hepatocellular carcinoma, CTLs cytotoxic T lymphocytes, Foxp3 forkhead box P3, HBeAg hepatitis B e antigen, AST aspartate aminotransferase, ALT alanine aminotransferase, AFP alpha-fetoprotein, CLIP Cancer of the Liver Italian Program, BCLC Barcelona Clinic Liver Cancer, AJCC American Joint Committee on Cancer, TNM tumor-node-metastasis.
***P value < 0.001.
aOnly patients with available data were analyzed.
bThe percentage of pre-S2 plus pre-S1 + pre-S2 deletion above 24.995 was defined as high percentage.
cP value was determined by the chi-square test.
dThe density of CTLs in tumor tissues above the mean density (18.03) was defined as high density.
eThe density of CD4+CD25+ cells in tumor tissues above the mean density (8.18) was defined as high density.
fThe density of granzyme B-expressing cells in tumor tissues above the mean density (5.53) was defined as high density.
gThe density of Foxp3-expressing cells in tumor tissues above the mean density (35.58) was defined as high density.