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. 2020 Dec 29;24(1):102006. doi: 10.1016/j.isci.2020.102006

Figure 3.

Figure 3

Stratification of biomarker levels using the MBT readout

Heatmap indicating per individual the αPGL-I IgM, IP-10, CRP, S100A12, and ApoA1 R values classified in three groups based on the association with disease as strong (dark red), intermediate (pink), or not associated (white) in the Bangladeshi and South Korean cohort. Strong association: R ≥ 2x median of the patient group, intermediate association: median of the patient group ≤ R < 2x median of the patient group, no association: R < median of the patient group (Table S1).

(A) R value classification of biomarkers in patients with multibacillary (MB) leprosy (Bangladesh: 21; South Korea: 19), patients with paucibacillary (PB) leprosy (Bangladesh: 15; South Korea: 6), and healthy controls (Bangladesh: 20; South Korea: 24).

(B) R value classification of biomarkers in household contacts (HCs; n = 25) and patients with other dermatological diseases (ODDs; n = 25) (South Korean cohort).

(C) Dots indicating which biomarker showed a different pattern relative to controls in patients with MB (orange) and PB (blue) leprosy, HC (green), and patients with ODDs (gray).