Table 2.

RNA-dependent RNA polymerase hits.

Dock ID	Compound name	Normal target	Glide Energy	DockScore	LipophilicEvdW	HBond	Electro	ExposPenal	RotPenal
A	Lactulose	Laxative & portal-systemic encephalopathy (PSE)	−67.99	−15.22	−2.9	−11.26	−2	0.11	0.19
B	Framycetin/Paromomycin	16S ribosomal RNA	−66.49	−14.87	−1.56	−6.87	−2	0.22	0.11
C	Amikacin/Arbekacin	16S ribosomal RNA	−73.4	−14.06	−1.87	−10.24	−2	0.19	0.11
D	Bekanamycin	Not Available	−63.88	−14.69	−2.31	−6.6	−2	0.2	0.06
E	Lividomycin A	Not Available	−64.68	−14.6	−2.22	−6.56	−2	0.18	0.11
F	Lapatinib Ditosylate	Blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts.	−51.39	−12.03	−1.31	−5.48	−2	0.01	0.11