Table 4.

Guanine-N7 methyltransferase (ExoN) Hits.

Dock ID	Compound name	Normal target	Glide Energy	DockScore	LipophilicEvdW	HBond	Electro	ExposPenal	RotPenal
A	Diosmin	Diosmin, a flavone that can be found in the plant Teucrium gnaphalodes. Is an agonist at the human aryl hydrocarbon receptor	−68.66	−13.26	−1.66	−6.01	−2	0.11	0.11
B	Hidrosmin	Capillary stabilizing agent	−71.34	−13.24	−2.01	−5.57	−2	0.05	0.11
C	N-Desmethyl-4-hydroxy tamoxifen beta-D-glucuronide (E/Z Mixture)	N/A	−72.69	−13.23	−1.77	−6.22	−2	0.48	0.11
D	Octane-1,3,5,7- tetracarboxylic acid	Carboxypeptidase A1	−68.77	−13.17	−1.65	−6.08	−2	0.28	0.11
E	Bempedoic acid	Metabolic activation affords ETC-1002-CoA, the pharmacologically active metabolite. ATP lyase (a.k.a. ATP synthase) plays an important part of cholesterol synthesis	−71.39	−13.15	−2.14	−5.48	−2	0.22	0.08
F	Bisindolylmaleimide IX	PKC Inhibitor, Potential anti-cancer activity	−50.6	−7.8	−4.5	−2.7	−0.7	0.0	0.3