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. 2021 Jan 15;12(1):84–97. doi: 10.4239/wjd.v12.i1.84

Table 1.

Summary of included studies

Ref.
Study duration
Population
Assessment of NAFLD
Intervention
No. of participants
Alam et al[18], 2018 52 wk NAFLD Biopsy Sitagliptin 100 mg QD + lifestyle modification 20
Lifestyle modification 20
Cui et al[19], 2017 24 wk NAFLD with prediabetes or early diabetes MRI Sitagliptin 100 mg QD 25
PBO 25
Hussain et al[20], 2016 12 wk NAFLD + dyslipidemia Ultrasound Vildagliptin 50 mg Bid 29
PBO 29
Macauley et al[21], 2015 6 mo T2DM with hepatic steatosis Imaging (CT or ultrasound) Vildagliptin 50 mg Bid 22
PBO 22
Joy et al[22], 2017 24 wk NASH Biopsy Sitagliptin 100 mg QD 6
PBO 6
Li et al[23], 2019 24 wk T2DM with NAFLD Imaging or biopsy Saxagliptin 5 mg QD 31
Glimepiride 2 mg QD 33
Glimepiride 2 mg QD + polyenephosphatidylcholine 456 mg TID 31
Yan et al[24], 2019 26 wk T2DM with NAFLD MRI Liraglutide 1.8 mg + metformin 24
Sitagliptin + metformin 27
Glargine 0.2 IU/Kg/d + metformin 24
Armstrong et al[25], 2016 48 wk T2DM with NASH Biopsy Liraglutide 1.8 mg QD 26
PBO 26
Cusi et al[26], 2018 6 mo T2DM with NAFLD/NASH Laboratory liver tests Duraglutide 1.5 mg QW 971
PBO 528
Fan et al[27], 2013 12 wk T2DM with NAFLD Ultrasound Exenatide 49
Metformin 68
Feng et al[28], 2017 24 wk T2DM with NAFLD Ultrasound Metformin 1000 mg Bid 29
Gliclazide 120 mg/d 29
Liraglutide 1.8 mg QD 29
Khoo et al[29], 2017 26 wk NAFLD MRI Liraglutide 3.0 mg QD 12
Diet and exercise 12
Shao et al[30], 2014 12 wk T2DM with NAFLD Ultrasound Exenatide 10 μg bid + glargine 30
Intensive insulin therapy 30
Tian et al[31], 2018 12 wk T2DM with NAFLD Ultrasound Liraglutide 0.6-1.2 mg QD 52
Metformin 1000-1500 mg/d 75
Eriksson et al[32], 2018 12 wk T2DM with NAFLD MRI Dapagliflozin 10 mg QD 21
PBO 21
Dapagliflozin 10 mg QD + OM-3CA 22
OM-3CA 4 g 20
Ito et al[33], 2017 24 wk T2DM with NAFLD Clinical laboratorytests or imaging Ipragliflozin 50 mg QD 32
Pioglitazone 15–30 mg QD 34
Kuchay et al[34], 2018 20 wk T2DM with NAFLD MRI Empagliflozin 10 mg QD 22
Control 20
Shibuya et al[35], 2018 6 mo T2DM with NAFLD Imaging (CT or ultrasound) Luseogliflozin 2.5 mg QD 16
Metformin 1500 mg QD 16
Shimizu et al[36], 2018 24 wk T2DM with NAFLD Transient elastography Dapagliflozin 5 mg QD 33
Control 24

NAFLD: Non-alcoholic fatty liver disease; MRI: Magnetic resonance imaging; T2DM: Type 2 diabetes mellitus; NASH: Nonalcoholic steatohepatitis; CT: Computed tomography.