GSEA analysis and clinical relevance of NDRG2 and ESR2. (A,B) GSEA analysis for NDRG2 (A) and ESR2 (B) in KEGG pathway-related gene sets; (C) boxplot showing the relationships between clinical stage and the expression levels of NDRG2 and ESR2, respectively; (D) Kaplan-Meier curves showing the correlation of NDRG2 and ESR2 expression with CRC patients. *, P<0.05. GSEA, gene set enrichment analysis; CRC, colorectal cancer.