Table 3. Correlation analysis of TP53 R249S mutation and TP53 expression in the GWAS and replication study.
| Subjects | Number | TP53 R249S mutation | |||
|---|---|---|---|---|---|
| Non-mutation group (n) | Mutation group (n) | OR* (95% CI) | P value* | ||
| GWAS | |||||
| Negative | 159 | 133 | 26 | 1 | |
| Positive | 247 | 132 | 115 | 4.46 (2.73–7.27) | <0.001 |
| NA | 79 | 55 | 24 | ||
| Replication | |||||
| Negative | 53 | 45 | 8 | 1 | |
| Positive | 181 | 116 | 65 | 3.15 (1.40–7.09) | 0.006 |
| NA | 24 | 17 | 7 | ||
*, OR and P value for univariate analysis of the logistic regression model. GWAS, genome-wide association study; OR, odds ratio; 95% CI, 95% confidence interval.