Table 5. Combined analysis of associated SNP genotypes and TP53 R249S mutation.
| SNPs | TP53 R249S mutation | OR (95% CI) | P | Test power | |
|---|---|---|---|---|---|
| Non-mutation | Mutation | ||||
| rs9930984 | |||||
| Additive | 0.85 | ||||
| GG | 26 | 3 | 1 | 3.06×10−4 | |
| GT | 79 | 19 | 2.08 (0.57–7.62) | 0.267 | |
| TT | 358 | 204 | 4.94 (1.48–16.52) | 0.010 | |
| Dominant | 0.84 | ||||
| GG + GT | 105 | 22 | 1 | ||
| TT | 358 | 204 | 2.27 (1.67–4.44) | 6.43×10−5 | |
| rs75218075 | |||||
| Additive | NA | ||||
| CC | 19 | 2 | 1 | 0.001 | |
| CT | 147 | 49 | 3.17 (0.71–14.89) | 0.130 | |
| TT | 307 | 187 | 5.79 (1.33–25.13) | 0.002 | |
| Dominant | 0.65 | ||||
| CC + CT | 166 | 51 | 1 | ||
| TT | 307 | 187 | 1.98 (1.38–2.85) | 2.16×10−4 | |
| rs8022091 | |||||
| Additive | 0.82 | ||||
| AA | 65 | 40 | 1 | 0.413 | |
| AC | 185 | 92 | 0.81 (0.51–1.29) | 0.371 | |
| CC | 209 | 94 | 0.73 (0.46–1.16) | 0.184 | |
| Dominant | 0.79 | ||||
| AA | 65 | 40 | 1 | ||
| AC + CC | 394 | 186 | 0.77 (0.50–1.18) | 0.228 | |
P values, OR, and 95% CI were calculated under the additive model using logistic regression adjusting for age, sex, race, smoking status, and drinking status. SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval.