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. 2020 Dec;11(6):1164–1185. doi: 10.21037/jgo-20-474

Figure 10.

Figure 10

The effect of colon cancer-associated transcript-1 (CCAT-1) on epithelial–mesenchymal transition (EMT) markers’ protein expressions in colon cancer cells cultured under different glucose concentrations. The protein expression of ZO-1 was significantly higher (t=33.050, P=0.019) in the LG-CCAT-1− group than in the LG-EV group. The protein expressions of E-cadherin and ZO-1 were significantly higher (t=31.079, P=0.020; t=143.200, P=0.004) and those of N-cadherin and vimentin were significantly lower (t=14.491, P=0.044; t=16.853, P=0.038) in the HG-CCAT-1− group than in the HG-EV group. The protein expression of ZO-1 was significantly lower (t=16.768, P=0.038), and vimentin was significantly higher (t=24.846, P=0.026) in the HG-CCAT-1− group than in the LG-CCAT-1− group. The protein expression of N-cadherin was significantly higher (t=34.353, P=0.019) in the HG-EV group than in the LG-EV group. HG-EV, empty vector transfected colon cancer cells cultured with high glucose; HG-CCAT-1−, CCAT-1– silenced colon cancer cells cultured with low glucose; LG-EV, empty vector transfected colon cancer cells cultured with low glucose; LG-CCAT1–, CCAT-1– silenced colon cancer cells cultured with low glucose.