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. 2020 Dec;11(6):1164–1185. doi: 10.21037/jgo-20-474

Figure 12.

Figure 12

The effect of colon cancer-associated transcript-1 (CCAT-1) on the volume of colon cancer xenografts in nude mice with different blood glucose concentrations. The tumor volume of nude mice was significantly lower in the NG-CCAT-1− group than in the NG-EV group (t=5.257, P=0.034); further, the tumor volume of nude mice was significantly lower in the HG-CCAT-1− group than in the HG-EV group (t=4.892, P=0.039). Finally, the tumor volume of nude mice in the HG-EV group was significantly higher than that in the NG-EV group (t=10.231, P=0.009). NG-EV, normal blood glucose nude mice transplanted with empty vector transfected colon cancer cells; NG-CCAT-1−, normal blood glucose nude mice transplanted with CCAT-1 silenced colon cancer cells; HG-EV, hyperglycemia nude mice transplanted with empty vector transfected colon cancer cells; HG-CCAT-1−, hyperglycemia nude mice transplanted with CCAT-1 silenced colon cancer cells.