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. 2020 Dec;11(6):1164–1185. doi: 10.21037/jgo-20-474

Figure 13.

Figure 13

The effect of colon cancer-associated transcript-1 (CCAT-1) on serum glucose, lactic acid, and insulin levels in nude mice with different blood glucose concentrations. The levels of serum glucose (t=13.369, P=0.001) and insulin (t=5.571, P=0.011) were significantly lower in the NG-CCAT-1− group than in the NG-EV group; the levels of serum glucose (t=17.689, P<0.001), lactic acid (t=5.033, P=0.037), and insulin (t=5.817, P=0.010) were significantly lower in the HG-CCAT-1− group than in the HG-EV group. Furthermore, the levels of serum glucose (t=28.352, P<0.001), lactic acid (t=4.539, P=0.045), and insulin (t=19.024, P<0.001) were significantly higher in the HG-CCAT-1− group than in the NG-CCAT-1− group. The levels of serum glucose (t=19.575, P<0.001) and insulin (t=8.560, P=0.003) were significantly higher in the HG-EV group than in the NG-EV group. HG-EV, nude mice with hyperglycemia transplanted with empty vector-transfected colon cancer cells; HG-CCAT-1−, nude mice with hyperglycemia transplanted with CCAT-1-silenced colon cancer cells; NG-EV, nude mice with normal blood glucose transplanted with empty vector-transfected colon cancer cells; NG-CCAT-1−, nude mice with normal blood glucose transplanted with CCAT-1-silenced colon cancer cells.