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. 2020 Dec;11(6):1164–1185. doi: 10.21037/jgo-20-474

Figure 8.

Figure 8

The effect of colon cancer-associated transcript-1 (CCAT-1) on the protein expression of Bcl2 and Bax in colon cancer cells cultured under different glucose concentrations. The protein expressions of Bcl-2 were significantly lower (t=4.666, P=0.043) and BAX were significantly higher (t=6.145, P=0.025) in the LG-CCAT-1− group than in the LG-EV group; the protein expressions of Bcl-2 were significantly lower (t=13.899, P=0.005) and Bax was significantly higher (t=389.730, P<0.001) in the HG-CCAT-1− group than in the HG-EV group. Furthermore, the protein expressions of Bcl-2 were significantly higher (t=7.641, P=0.017), and Bax was significantly lower (t=27.601, P=0.001) in the HG-CCAT-1− group than in the LG-CCAT-1− group. Finally, the protein expressions of Bcl-2 were significantly higher (t=15.348, P=0.004), and Bax was significantly lower (t=5.971, P=0.027) in the HG-EV group than in the LG-EV group. HG-EV, empty vector transfected colon cancer cells cultured with high glucose; HG-CCAT-1−, CCAT-1-silenced colon cancer cells cultured with low glucose; LG-EV, empty vector transfected colon cancer cells cultured with low glucose; LG-CCAT-1−, CCAT-1– silenced colon cancer cells cultured with low glucose.