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. 2020 Dec;11(6):1164–1185. doi: 10.21037/jgo-20-474

Figure 9.

Figure 9

The effect of colon cancer-associated transcript-1 (CCAT-1) on the mRNA expressions of Bcl2 and Bax in colon cancer cells cultured under different glucose concentrations. The mRNA expressions of Bcl-2 decreased (t=13.629, P=0.005), and Bax increased (t=5.2577, P=0.034) significantly in LG-CCAT-1− group compared with those in the LG-EV group. The mRNA expressions of Bcl-2 decreased (t=18.301, P=0.003), and Bax increased (t=14.658, P=0.005) significantly in the HG-CCAT-1− group compared with those in the HG-EV group. Furthermore, the mRNA expressions of Bcl-2 increased (t=13.408, P=0.006), and Bax decreased (t=11.893, P=0.007) significantly in the HG-CCAT-1− group compared with those in the LG-CCAT-1− group. Finally, the mRNA expressions of Bcl-2 increased (t=13.629, P=0.005), and Bax decreased (t=5.257, P=0.034) significantly in the HG-EV group compared with those in the LG-EV group. LG-EV, empty vector transfected colon cancer cells cultured with low glucose; LG-CCAT-1−, CCAT-1 silenced colon cancer cells cultured with low glucose; HG-EV, empty vector transfected colon cancer cells cultured with high glucose; HG-CCAT-1−, CCAT-1 silenced colon cancer cells cultured with high glucose.