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. 2020 Dec;9(6):2555–2571. doi: 10.21037/tau-19-911

Table 2. The gene ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment among predicted miRNAs and co-DEGs.

Genes Predicted miRNAs Category Function P value
ALB hsa-miR-496 KEGG pathway Steroid hormone biosynthesis 5.27E−08
hsa-miR-141-3p Hippo signaling pathway 2.02E−05
Endocrine and other factor-regulated calcium reabsorption 2.47E−05
GO terms Macromolecular complex assembly 0.00030452
Epidermal growth factor receptor signaling pathway 0.000423173
Post-translational protein modification 0.000428322
G2/M transition of mitotic cell cycle 0.000515818
Keratan sulfate biosynthetic process 0.00053589
Fc-epsilon receptor signaling pathway 0.000720702
Keratan sulfate metabolic process 0.001811958
Sulfur compound metabolic process 0.001941431
Phospholipid metabolic process 0.005110673
ECM-receptor interaction 1.46E−48
Mucin type O-glycan biosynthesis 8.96E−09
KEGG pathway PI3K-Akt signaling pathway 0.006961302
TNF signaling pathway 0.009107875
Signaling pathways regulating pluripotency of stem cells 0.009974988
COL1A2 hsa-miR-29c-3p GO terms Fc-epsilon receptor signaling pathway 3.59E−17
hsa-let-7b-5p neurotrophin TRK receptor signaling pathway 2.73E−15
hsa-let-7c-5p Extracellular matrix disassembly 1.20E−12
hsa-let-7f-5p Post-translational protein modification 3.56E−12
hsa-miR-29a-3p Extracellular matrix organization 3.92E−09
Nucleobase-containing compound catabolic process 8.99E−09
Platelet activation 1.77E−08
COL3A1 hsa-miR-29c-3p KEGG pathway ECM-receptor interaction 8.17E−49
hsa-miR-29a-3p Mucin type O-glycan biosynthesis 7.54E−09
hsa-miR-29b-3p Focal adhesion 0.001207023
hsa-miR-98-5p PI3K-Akt signaling pathway 0.006207862
hsa-let-7b-5p GO terms Fc-epsilon receptor signaling pathway 4.44E−17
Neurotrophin TRK receptor signaling pathway 3.49E−15
Extracellular matrix disassembly 1.42E−12
Post-translational protein modification 4.28E−12
Cellular protein metabolic process 1.98E−11
FN1 hsa-miR-200c-3p KEGG pathway Thyroid hormone signaling pathway 0.024934027
hsa-miR-200b-3p Cysteine and methionine metabolism 0.028989042
hsa-miR-429 Sphingolipid metabolism 0.047606983
hsa-miR-199a-3p ErbB signaling pathway 0.048121598
hsa-miR-144-3p GO terms Toll-like receptor TLR1:TLR2 signaling pathway 0.010695034
Toll-like receptor TLR6:TLR2 signaling pathway 0.010695034
Toll-like receptor 10 signaling pathway 0.017791067
G6PC hsa-miR-200c-3p KEGG pathway ECM-receptor interaction 1.62E−70
hsa-miR-429 Focal adhesion 3.49E−05
hsa-miR-200b-3p PI3K-Akt signaling pathway 0.000700807
hsa-miR-3163 Signaling pathways regulating pluripotency of stem cells 0.001671859
hsa-miR-29a-3p GO terms Cell death 0.000888739
Fibroblast growth factor receptor signaling pathway 0.001026574
Cellular lipid metabolic process 0.0010844
MyD88-independent toll-like receptor signaling pathway 0.001319258
PCK1 hsa-miR-1297 KEGG pathway Hippo signaling pathway 0.000298106
hsa-miR-548m Thyroid hormone signaling pathway 0.024032656
hsa-miR-330-3p Sphingolipid metabolism 0.037579593
hsa-miR-101-3p Adherens junction 0.037579593
hsa-miR-3163 GO terms Cellular component disassembly involved in execution phase of apoptosis 3.19E−05
Cell proliferation 0.000266671
Cellular protein metabolic process 0.000394966
Macromolecular complex assembly 0.00042068
Fc-epsilon receptor signaling pathway 0.000562009
Response to stress 0.000562009