Figure 3. Recombinant P450 screen for sudoxicam and meloxicam bioactivation.
(A.) 400 µM sudoxicam and (B.) 400 µM meloxicam were incubated with recombinant P450s to measure glyoxal (green circles) and methylglyoxal (purple squares) formation. Significant differences from background (dashed line) were determined based on p < 0.05 calculated using Student’s T test. Error bars denote standard error. (2 column)