Skip to main content
. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Toxicol Lett. 2020 Nov 27;338:10–20. doi: 10.1016/j.toxlet.2020.11.015

Table 2.

Scaled contributions of P450 isozymes to in vivo hepatic sudoxicam and meloxicam clearance and/or bioactivation

Scaled contributionsa of individual isozymes for each reactionb
Substrate Metabolite CYP1A2 CYP2C8 CYP2C9 CYP2C19 CYP3A4 Total
sudoxicam glyoxal - 5.54 - 0.285 0.736 6.55
meloxicam methylglyoxal 0.457 - - - - 0.457
5-hydroxymethyl-meloxicam - - 2.56 - 0.234 2.79
a

Units: Vmax/Km = pmol/min/mg protein/µM substrate

b

Calculations based on extrapolations of kinetic efficiencies and reported levels of P405 isozymes (pmol/mg protein) as described under Materials and Methods.