Table 3.
Relative contributions of P450 isozymes to in vivo hepatic sudoxicam and meloxicam clearance and/or bioactivation
| Substrate | Metabolite | Percent contributions of individual isozymes for each reactiona |
||||
|---|---|---|---|---|---|---|
| CYP1A2 | CYP2C8 | CYP2C9 | CYP2C19 | CYP3A4 | ||
| sudoxicam | glyoxal | - | 84.4 | - | 4.3 | 11.2 |
| meloxicam | methylglyoxal | 100 | - | - | - | - |
| 5-hydroxymethyl-meloxicam | - | - | 91.6 | - | 8.4 | |
a
Calculations based on extrapolations of kinetic efficiencies and reported levels of P405 isozymes as described under Materials and Methods.