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Azilsartan decreased LPS-induced expression of MMP-2 and MMP-9 in U937 macrophages. Cells were treated with 1 μg/mL LPS in the presence or absence of azilsartan (5, 10 μM) for 24 h. (A) mRNA of MMP-2 and MMP-9 and (B) protein levels of MMP-2 and MMP-9 (****P < 0.0001 vs vehicle group; ##P < 0.01, ####P < 0.0001 vs LPS group).
