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. 2021 Jan 14;8:3. doi: 10.1186/s40662-020-00226-y

Table 1.

Study design, anti-viral regime, and steroid regime in studies on the management of CMV endotheliitis

Study Study location Study design No. of eyes (patients) Anti-viral regime Steroid regime Mean duration of anti-viral treatmenta
Chee [48] Singapore retrospective interventional case series 12 (10)

5 patients

 • 6-week of intravenous ganciclovir 5 mg/kg twice daily

 • followed by 6 weeks of oral ganciclovir 1 g thrice daily

5 patients

 • 6 weeks of oral valganciclovir 900 mg twice daily

 • followed 6-week of oral ganciclovir 900 mg daily

topical prednisolone acetate 1% twice daily, tapered off over 3 months 12 weeks
Chiang [49] Taiwan, China case report 1 (1)  • oral valganciclovir 900 mg twice daily 1-week of topical prednisolone 1% 4 times a day for 1 week 4 months
Choi [50] South Korea case report 1 (1)

 • 2 intravitreal ganciclovir injections (unspecific time interval between injections)

 • topical ganciclovir 0.15% every 2 h

topical prednisolone acetate 1% 4–6 times daily N/A
Fan [51] Taiwan, China retrospective interventional case series 10 (9)  • topical ganciclovir 0.5% every 2 h for 1 month, then tapered to 4 times per daily topical prednisolone acetate 1% twice daily, then tapered to once or twice daily 48 months
Hwang [52] Taiwan, China case report 1 (1)  • oral valganciclovir (details N/A) topical prednisolone acetate 1% 4 times a day 2 months
Hwang [53] Taiwan, China retrospective interventional case series 13 (13)  • topical ganciclovir 2% every 2 h for 2 weeks, then tapered to 4 times a day topical prednisolone acetate 1% 4 times a day for 2 weeks, then tapered to twice daily 24.5 months
Kam [54] Hong Kong, China retrospective interventional case series 17 (16)

13 patients

 • oral valganciclovir 900 mg twice daily and topical ganciclovir ointment

3 patients

 • topical ganciclovir ointment

prednisolone acetate 1% ophthalmic suspension 12.5 months
Koizumi [55] Japan retrospective, consecutive, multicenter case series. 8 (8)  • topical ganciclovir 0.15% 6 times per day topical 0.1% fluorometholone eye drops 4 times daily 12 weeks
Pavan-Langston [56] USA case report 1 (1)  • topical ganciclovir 0.15% every 2 h topical prednisolone 1% once daily 4.5 months
Wong [57] Hong Kong, China retrospective interventional case series 13 (11)

 • 2-week loading dose of oral valganciclovir 900 mg twice daily

 • followed by 450 mg twice daily as maintenance

topical prednisolone acetate 1, 0.5% loteprednol etabonate eye drops, or 1% dexamethasone ranging from 4 to 38 weeks
Yamauchi [58] Japan case report 1 (1)  • 5 weeks oral valganciclovir 1800 mg/dayfollowed by 900 mg/day as maintenance topical dexamethasone 0.1% 4 times a day 3 months
Yu [59] China retrospective interventional case series 16 (15)

 • oral ganciclovir 1000 mg/60 kg 3 times daily for 4 weeks

 • followed by 500 mg/60 kg 3 times daily for 8 weeks

 • multiple intravitreal ganciclovir injections (mean 3.47 injections)

 • topical ganciclovir 0.15% gel 4 times per day

topical prednisolone 0.1% 4 times daily with gradual tapering N/A

aincludes induction and maintenance period

N/A = not available

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