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. 2019 Nov;21(6):1053–1066. doi: 10.1016/j.jmoldx.2019.06.011

Figure 6.

Figure 6

Gene enrichment in microsatellite instability–high (MSI-H) or MSI-stable (MSS) tumors. Pan-tumor enrichment of genes in MSI-H (log2 odds ratio > 1) or MSS (log2 odds ratio < 1). Circle sizes represent the frequency of gene alteration in either MSI-H tumors (orange) or MSS tumors (teal). Circles representing genes without significant enrichment (dark blue) are not scaled to size. Multiple hypothesis–corrected –log10 P values are on the y axis. A: All genes with at least 25 samples are displayed. Top panel: Pathway-related (Supplemental Table S6) or mismatch repair (MMR) related genes with P < 0.05 and P > 1e-09 are labeled. P values are capped at 1e-09 for visualization purposes. Bottom panel: Enlargement of highly significantly enriched genes (P < 1e-09). P values are capped at 1e-17 for visualization purposes. Pathway-related (Supplemental Table S6) or MMR-related genes are labeled. B: List of all genes with P < 1e-09 with odds ratio (>1 enriched in MSI-H, and <1 enriched in MSS) and multiple hypothesis–corrected P value. Odds ratios corresponding with MSI-H enrichment are coded in orange, and those with MSS are coded in teal. Genes included in pathway analyses are color coded, and the pathway is listed. FDR, false discovery rate; PI3K, phosphatidylinositol 3-kinase.