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. 2021 Jan 14;21:16. doi: 10.1186/s12902-020-00670-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Serum concentrations of TSH and TSH receptor antibody (TRAb) and mean daily doses of methimazole during 24 years of continuous methimazole treatment. All 27 patients continued therapy for at least 15 years, 16 patients until 20 years and 11 patients until 24 years. Daily doses of methimazole to maintain euthyroidism decreased to mean of 3.4 ± 1.0 and 2.8 ± 1.7 mg daily, by 15 and 24 years of therapy; suppressed serum TSH was not seen in any patient after 7 years of treatment. Serum TRAb was normal in all patients during methimazole treatment