Table 1.
Association between clinicopathological features, STOML2 expression and survival
| Factors | OS | TTR | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate P value | Multivariate | Univariate P value | Multivariate | |||||
| HR | 95% CI | P value | HR | 95% CI | P value | |||
| Hepatitis B e antigen: positive versus negative | 0.038 | 1.547 | 1.033–2.318 | 0.034 | 0.013 | 1.709 | 1.169–2.498 | 0.006 |
| AFP (≤ 400 versus > 400 ng/ml) | 0.024 | NS | 0.005 | NS | ||||
| Tumor differentiation: low versus high | 0.027 | 1.920 | 1.192–3.095 | 0.007 | 0.235 | NA | ||
| Vascular invasión(yes vs. no) | < 0.001 | NS | 0.001 | NS | ||||
| Tumor size (≤ 5 vs. > 5 cm) | < 0.001 | 2.963 | 1.864–4.710 | < 0.001 | < 0.001 | 2.108 | 1.392–3.193 | < 0.001 |
| Tumor number (single versus. multiple) | 0.004 | NS | 0.008 | NS | ||||
| UICC TNM stage (I vs. II vs. IIIA) | < 0.001 | 1.703 | 1.274–2.275 | < 0.001 | < 0.001 | 1.548 | 1.186–2.022 | 0.001 |
| STOML2 (low vs. high) | 0.001 | 1.596 | 1.057–2.410 | 0.026 | 0.003 | 1.638 | 1.120–2.395 | 0.011 |
OS overall survival, TTR time to recurrence, CI, confidence interval, HR hazard ratio, NA not adopted, NS not significant, AFP α-fetoprotein, UICC International Union Against Cancer, TNM tumor-node-metastasis, STOML2 Stomatin-like protein 2