Table 1.
The link between the functional measures and the underlying biology.
| DiffusionMRI | Tissue oxygenation MRI |
| cellularity | hypoxia |
| extracellular volume | |
| membrane permeability | Magnetization transfer MRI |
| tortuosity | cellularity |
| microcirculation in capillary network (IVIM) | fibrosis |
| hypoxia (IVIM) | HP 13C MRI |
| microstructural organisation of tissue (DTI) | pyruvate glycolysis metabolites |
| DCE-MRI | lactate |
| tumor vasculature | alanine |
| blood vessel permeability | bicarbonate |
| extravascular extracellular volume | |
| plasma volume | |
| 1H MRS | |
| metabolites | |
| citrate | |
| choline | |
| creatine | |
| polyamines |