Table 1. Predicted Binding Energy of Docked Ligands with AKR1B1.

ligands	ΔG (kcal/mol)	ligands	ΔG (kcal/mol)
(−)-kusunokinin	–11.11	suggested potential ARIs
carboxylic ARIs		oleanolic acid	–10.90
zenarestat	–11.54	AD5467	–10.84
zopolrestat	–11.21	γ-mangostin	–9.63
sulindac	–11.19	arctiin	–9.85
lidorestat	–10.92	arctigenin	–9.55
IDD1219	–10.86	10C	–9.32
epalrestat	–10.57	caffeic acid phenethyl ester	–9.08
IDD740	–10.52	substrates
IDD594	–9.83	Retinol	–9.91
IDD552	–9.53	PGH2	–9.71
tolrestat	–9.38	substrate analogs
tolmetin	–9.22	UVI2008	–10.71
alrestatin	–8.92	PGA1	–10.01
hydantoin ARIs
minalrestat	–10.88
ranirestat	–10.41
fidarestat	–7.50
sorbinil	–6.92