Table 2. MM/GBSA Binding Energy of (−)-Kusunokinin and Selective ARIs toward AKR1B1.

ligand	MM/GBSA binding energy (kcal/mol)
(−)-kusunokinin	–42.23 ± 0.09
zenarestat	–29.63 ± 0.10
minalrestat	–36.55 ± 0.07
epalrestat	–38.96 ± 0.08