Table 3. Physicochemical Properties of the Selected Compounds.

comp. no.	fraction C sp3a	no. of rotatable bonds	HBAb	HBDc	i log Pd	molar refractivity	log Se	TPSAf
7	0.06	4	2	0	3.17	86.29	MS	56.01
8	0.17	3	2	0	2.55	65.82	S	56.01
16	0.08	7	4	0	3.67	122.33	PS	86.72
17	0.52	20	4	0	6.57	169.95	I	86.72
18	0.30	10	4	0	4.27	121.88	PS	86.72
19	0.16	6	4	0	3.05	101.86	PS	86.72
20	0.19	9	6	0	3.45	113.55	PS	113.02
21	0.31	8	6	0	2.38	93.08	MS	113.02
22	0.04	6	4	0	3.86	125.62	PS	86.72
23	0.04	6	5	0	3.92	117.88	PS	86.72
24	0.04	6	4	0	4.19	127.94	PS	86.72
25	0.11	5	4	0	3.63	105.15	PS	86.72
26	0.11	5	5	0	3.37	97.41	PS	86.72
27	0.11	5	4	0	3.64	107.47	PS	86.72

^aThe ratio of sp³ hybridized carbons over the total carbon count of the molecule.

^bNumber of hydrogen bond acceptors.

^cNumber of hydrogen bond donors.

^dLipophilicity.

^eWater solubility (SILICOS-IT [I = insoluble, PS = poorly soluble, MS = moderately soluble, and S = soluble]).

^fTPSA (Ų).