Table 2.
Results for OARs: Parameters of the cumulative dose distributions that emerged from the separated and the integrated planning strategy. Bold denotes statistical significance at level p < 0.05.
| Volume (n) | Parameter | Separated Strategy Median (IQR) | Integrated Strategy Median (IQR) | ΔMedian (%) | p | |||
|---|---|---|---|---|---|---|---|---|
| Temporal lobe ipsilat. (14) |
Dmean | 20.4 | (3.1) | 17.1 | (2.2) | −3.3 | (−16%) | <0.001 |
| D1% | 65.4 | (8.8) | 60.9 | (12.5) | −4.5 | (−7%) | <0.001 | |
| Temporal lobe contralat. (6) |
Dmean | 8.4 | (7.4) | 5.5 | (6.1) | −2.9 | (−35%) | 0.03 |
| D1% | 19.9 | (17.6) | 14.4 | (14.3) | −5.5 | (−28%) | 0.03 | |
| Brainstem (10) | D50% | 15.8 | (8.4) | 13.8 | (12.4) | −2.0 | (−13%) | 0.002 |
| D1% | 35.3 | (18.7) | 30.4 | (21.9) | −4.9 | (−14%) | 0.01 | |
| Spinal cord (10) | Dmean | 8.1 | (5.1) | 5.1 | (5.4) | −3.0 | (−37%) | 0.002 |
| D1% | 22.5 | (7.7) | 18.2 | (11.4) | −4.2 | (−19%) | 0.004 | |
| Posterior eyeball ipsilat. (14) |
Dmean | 23.9 | (20.3) | 20.2 | (20.8) | −3.6 | (−15%) | 0.005 |
| D1% | 49.8 | (35.8) | 44.9 | (40.0) | −4.8 | (−10%) | 0.06 | |
| Posterior eyeball contralat. (6) |
Dmean | 6.8 | (8.4) | 5.1 | (5.9) | −1.7 | (−25%) | 0.03 |
| D1% | 12.9 | (15.6) | 10.3 | (14.0) | −2.6 | (−20%) | 0.03 | |
| Optic nerve ipsilat. (14) |
D50% | 28.3 | (24.4) | 26.2 | (23.5) | −2.1 | (−8%) | <0.001 |
| D1% | 46.5 | (23.3) | 45.8 | (38.1) | −0.7 | (−2%) | 0.03 | |
| Optic nerve contralat. (6) |
D50% | 11.5 | (17.2) | 7.3 | (14.5) | −4.3 | (−37%) | 0.03 |
| D1% | 14.9 | (29.3) | 11.2 | (25.8) | −3.7 | (−25%) | 0.03 | |
| Optic chiasm (9) | D50% | 21.0 | (19.5) | 18.3 | (16.0) | −2.8 | (−13%) | 0.01 |
| D1% | 42.0 | (28.7) | 41.5 | (32.6) | −0.5 | (−1%) | 0.055 | |
| Parotid gland ipsilat. (11) | Dmean | 23.8 | (5.8) | 20.5 | (11.1) | −3.3 | (−14%) | 0.001 |
| Parotid gland contralat. (6) | Dmean | 6.7 | (1.3) | 5.1 | (1.4) | −1.7 | (−25%) | 0.03 |
| Subject volume (9) | ID | 61.0 | (19.2) | 53.4 | (27.7) | −7.6 | (−12%) | 0.07 |