Table 4.
Overall analysis of miR-34a expression association with clinicopathologic characteristics
| Clinicopathological characteristics | Num. of studies | Num. of patients | Pooled OR (95%CI) | Heterogeneity | ||
|---|---|---|---|---|---|---|
| Fixed | Random | I2 | p-value | |||
| Gender (male vs. female) | 7 | 647 | 0.776 (0.566–1.065) | 0.777 (0.565–1.067) | 0.0% | 0.888 |
| Tumor Size (≤5 vs > 5 cm) | 3 | 326 | 0.736 (0.460–1.177) | 0.284 (0.433–1.288) | 20.5% | 0.284 |
| Lymphatic Metastasis (YESvs.NO) | 6 | 571 | 3.231 (2.237–4.666) | 3.200 (2.210–4.635) | 0.0% | 0.754 |
| TNM stage (III + IV vs. I + II) | 5 | 458 | 2.468 (1.698–3.588) | 2.896 (1.302–6.442) | 74.4% | 0.004 |
| Differentiation (poor vs. others) | 6 | 597 | 2.228 (1.538–3.228) | 2.373 (1.430–3.938) | 35.7% | 0.169 |
Abbreviations: 95%CI 95% confidence interval, Fixed, fixed effects model, OR Odds ratio, Random, random pooling model