Figure 1.
Longitudinal changes in lymphocytes and platelets.
(A) CHRONIC lymphocyte counts (day −170 to day −15) preinfection versus 7 days during infection in the Manchester cohort (∗∗∗∗P < 0.0001). (B) Lymphocyte count IMMED (last test pre-infection) versus 7 days during infection in the Manchester cohort (∗∗∗P < 0.001). (C) Boxplot of day 0 lymphocyte count (total cohort) grouped by diagnosis of haematological malignancy. (D) CHRONIC platelet counts preinfection versus 7 days during infection in the Manchester cohort (∗∗∗P = 0.0008). (E) Platelet count IMMED preinfection versus 7 days during infection in the Manchester cohort (∗P = 0.03). (F) Boxplot of lymphocyte count according to worst outcome in the entire cohort measured at day 0. Discharge, discharged within 24 hours; Inpt for non-COVID-19 reason, inpatient due to reason other than COVID-19 and outcome not altered by infection; COVID-19 no O2, admitted due to COVID-19 infection but did not require oxygen; admitted plus O2, admitted due to COVID-19 and required oxygen; admitted plus ICU, admitted due to COVID-19 and required intensive care; COVID-19 death, death due to other. (G) Boxplot of lymphocyte count grouped by oxygen requirement in the entire cohort measured at day 0. (H) Boxplot of lymphocyte count grouped by whether patient died in the entire cohort measured at day 0. COVID-19, coronavirus disease 2019; ICU, intensive care unit.