Figure 3.
Longitudinal changes in C-reactive protein.
(A) Boxplot of CRP according to worst outcome in the entire cohort measured at day 0. Discharge, discharged within 24 hours; Inpt for non-COVID-19 reason, inpatient due to reason other than COVID-19 and outcome not altered by infection; COVID-19 no O2, admitted due to COVID-19 infection but did not require oxygen; admitted plus O2, admitted due to COVID-19 and required oxygen; admitted plus ICU, admitted due to COVID-19 and required intensive care; COVID-19 death, death due to other. (B) Boxplot of CRP grouped by oxygen requirement in the entire cohort measured at day 0. (C) Boxplot of CRP grouped by whether patient died in the entire cohort measured at day 0. (D) Heatmap of the CRP level (darker red = higher CRP) against time (pre/post SARS-CoV-2-positive PCR test). Each patient record is represented by a row and each column by a timepoint. Hierarchical clustering is based on values from day 0 to 7. (E) Scatter graph of CRP versus neutrophil count measured at day 0 in the entire cohort. Blue, required oxygen; red, did not require oxygen; triangle, died from non-COVID-19 cause; cross, died due to COVID-19. COVID-19, coronavirus disease 2019; CRP, C-reactive protein; ECOG, Eastern Cooperative Oncology Group; ICU, intensive care unit; SARS-CoV, severe acute respiratory syndrome coronavirus 2.