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American College of Cardiology summary of available reversal agents and suggested use.21 aPCC, activated PCC; 4F-PCC, four-factor PCC
| Reversal agent | Vitamin K antagonist (warfarin) | Factor IIa inhibitor (dabigatran) | Factor Xa inhibitor (apixaban, edoxaban, and rivaroxaban) |
|---|---|---|---|
| 4F-PCC | First line | Second line | First line |
| aPCC | Not indicated | Second line | Second line |
| Idarucizumab | Not Indicated | First line | Not indicated |
| Plasma | If 4-PCC is unavailable | Not indicated | Not indicated |
