Table 4. Matrix Effects and Recoveries of Artemisinin, Deoxyartemisinin, and 10-Deoxoartemisinin in Rat Plasma Determined by the LC–MS/MS Technique (n = 5).
| compound | spiked concentration (ng/mL) | recovery (%) | RSD (%) | matrix effect (%) | RSD (%) |
|---|---|---|---|---|---|
| artemisinin | 2.00 | 89.8 | 1.28 | 93.5 | 4.11 |
| 50.0 | 88.2 | 2.15 | 94.4 | 3.58 | |
| 800 | 85.8 | 2.71 | 92.1 | 4.61 | |
| deoxyartemisinin | 2.00 | 88.3 | 2.96 | 91.9 | 5.34 |
| 50.0 | 92.7 | 3.87 | 87.3 | 7.92 | |
| 800 | 89.7 | 3.67 | 90.3 | 4.34 | |
| 10-deoxoartemisinin | 2.00 | 86.8 | 8.41 | 91.3 | 4.59 |
| 50.0 | 89.4 | 6.45 | 92.5 | 8.55 | |
| 800 | 92.6 | 9.42 | 89.4 | 5.70 |