Table 3.
IL‐17 family of cytokine and stroke
| IL‐17 subtype | Length (aa) | Homology with IL‐17A (%) | Expression cells | Receptor(s) | Reception cells | Functions | Stroke | Ref. |
|---|---|---|---|---|---|---|---|---|
| IL‐17A | 155 | 100 | γδ T cells, NKT cells, NK cells, ILC3s, CD8+T cells and neutrophils | IL17RA/IL‐17RC | Lymphocytes, endothelial cells, astrocytes, microglia | Pro‐inflammatory, neutrophil recruitment, destroy BBB | Pro‐inflammatory, neutrophil recruitment, destroy BBB | 29, 30 |
| IL‐17B | 180 | 29 | Pancreas, small intestine, stomach, neurons, epithelial cells | IL‐17RB | Fibroblasts, THP‐1 cells, stromal cells | Pro‐inflammatory, tissue regeneration, | – | 21, 112, 114 |
| IL‐17C | 197 | 23 | Prostate, epithelial cells | IL‐17RE/IL‐17RA | Monocyte, Th17 cells | Pro‐inflammatory, neutrophil recruitment | – | 21, 116, 117 |
| IL‐17D | 202 | 25 | Muscle, brain, heart, lung, pancreas, adipose tissue | Remain unknown | Endothelial cell and myeloid progenitor | Recruitment chemokines, anti‐tumour, antiviral | – | 22, 120 |
| IL‐17E | 161 | 17 | Epithelial cells, Th2 cells, eosinophils, mast cells, brain endothelial cells | IL‐17RB/IL‐17RA | NKT cells, basophils, eosinophils, mast cells, endothelial cells, macrophages, dendritic cells, ILC2s | Induce the immune response of Th2, suppress the immune response of Th1/Th17 | – | 23, 121 |
| IL‐17F | 153 | 50 | Monocytes, mast cells, basophils, mucosal epithelial cells, Th17, CD8 cells, γδ TCR+ T cells, NK, NKT, LTi | IL17RA/IL‐17RC | Non‐hematopoietic cell | Neutrophil recruitment, immunity to extracellular pathogens in inflammatory bowel disease and asthma | Pro‐inflammatory, neutrophil recruitment, destroy BBB | 35 |