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. Author manuscript; available in PMC: 2021 Jan 14.
Published in final edited form as: ACS Infect Dis. 2020 Jun 9;6(7):1587–1598. doi: 10.1021/acsinfecdis.9b00515

Figure 2.

Figure 2.

Comparison of D-amino acid derived structures modified for fluorescent detection and positron emission tomography (PET) imaging, with the sites of modification marked in red. (A) Two D-amino acid structures incorporating hydroxycoumarin and nitrobenzofuran-derived fluorophores, HADA and NADA respectively (Kuru et al. 2012). (B) Two 11C-labelled amino acids D-[α−11C]met (Neumann et al. 2017) and D-[3-11C]ala (Parker et al. 2020) with the 11C nucleus highlighted in red. (C) The enantioselective radiosynthesis of D-[3-11C]ala from an achiral glycine-derived precursor via reaction with 11C methyl iodide in the presence of a cinchonidinium-derived phase-transfer catalyst.