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Comparison between optical imaging and radionuclide-based PET and SPECT imaging.
| OPTICAL | PET/SPECT | |
|---|---|---|
| In vitro analysis | Yes | Yes |
| In vivo analysis | Yes | Yes |
| Penetrating depth | ~cm | Full body |
| Activatable | Yes | No |
| Detected component | Fluorophore | Radionuclide |
| Detection method | Photons | Positrons/Gamma rays |
| Concentration | nM | fM-pM |
| Instrumentation | Smaller, more portable | Larger, PET/CT or PET/MR |
