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. Author manuscript; available in PMC: 2021 Oct 20.
Published in final edited form as: J Am Coll Cardiol. 2020 Oct 20;76(16):1878–1901. doi: 10.1016/j.jacc.2020.08.042

Figure 1: Non-necrotizing Granulomas.

Figure 1:

A: Early stage sarcoidosis (H&E stain, 20x) with a discrete perivascular granuloma (yellow arrows) comprised of epithelioid histiocytes, multinucleated giant cells, sparse lymphocytes and a lack of dense hyalinized collagen fibrosis. B: Late stage sarcoidosis (H&E stain, 20x) with a subpleural hyalinized nodule containing abundant dense eosinophilic hypocellular collagen fibrosis surrounding and bridging discrete granulomas (black arrows) with sparse lymphocytes. There prominent concentric lamellar fibrosis surrounding the granulomas, a finding characteristic of sarcoid granulomas association with scarring. Curtesy of Dr. M. A. Judson.