Extended Data Fig. 5 |. Rel gene deletion in macrophage results in decreased expression of inflammatory genes.

BMDMs from WT and Rel^−/− mice were treated with vehicle or LPS (100 ng/mL) for 1 hour and gene microarray analysis was performed for ~30,000 murine genes. Ingenuity Pathway Analysis was performed to identify c-Rel-regulated genes that were downstream of LPS response. Blue genes were decreased, and red genes were increased in Rel^−/− cells as compared to WT cells, after LPS treatment.