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. Author manuscript; available in PMC: 2021 Jan 14.
Published in final edited form as: Nat Cancer. 2020 May 18;1(5):507–517. doi: 10.1038/s43018-020-0061-3

Fig. 7. c-Rel inhibitor blocks human MDSCs.

Fig. 7.

a, The degree of suppression of human CD8+ T cell proliferation by human MDSCs generated from human PBMCs with or without the c-Rel inhibitor. n=3 biologically independent cultures/group (**, P<0.01).

b, Relative mRNA levels of ARG1 and CEBPB in human MDSCs generated with or without the c-Rel inhibitor (5μM). n=3 biologically independent cultures/group (*, P=0.01694; ***, P<0.0001).

c, A working model for the c-Rel myeloid checkpoint of anti-tumor immunity. Please see text for details.

Statistical significance was determined by two-tailed unpaired t-test (a-b). Error bars indicate s.e.m.