Table 1.
Spitz neoplasms with 11p gains.
| Case | Age | Gender | Site | Cytogenetics* | Surface | Silhouette | Epidermal changes | Paucicel | Growth pattern | Sclerosis | Borders | Cytomorph | Multinucl | Mit | Pigmt | Solar elast | Inflam |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 12 | F | Jaw line | +11p, −8p (subset) | R/Pa | NE | Y | N | Ns, Fa | Mi | NE | E, Sp | Fo | 1 | It | NE | Pv |
| 2 | 18 | F | Back | +11 p | R/Pa | W | Y | N | S, Fa | Mi | I | E, Sp | A | 1 | Fo | A | Pv |
| 3 | 20 | M | Helix | +11p | R/Pa | NE | Y | N | Ns | Mi | I | E, Sp | A | 2 | Fo | NE | Pv |
| 4 | 41 | M | Back | +11p | Fl | W | Y | N | Fa | P | I | E, Sp | P | 1 | N | A | Pv |
| 5 | 11 | F | Helix | +11p | R | W | Y | N | Fa, SC | Mi | I | E, Sp | Fo | 0 | Fo | A | Pv |
| 6 | 18 | M | UE | +11p | R | W | Y | N | Fa | P | I | E, Sp | Fo | 0 | Fo | A | Pv |
| 7 | 66 | F | UE | +11p | Fl | Pl | N | Y | SC | A | I | E, Sp | Fo | 0 | N | Mi | Pv |
| 8 | 27 | M | Forehead | +11p | R | W | Y | N | Fa | Mi | I | E, Sp | Fo | 1 | N | Mi | Pv |
| 9 | 3 | M | Cheek | +11p | R | W | Y | N | S | Mi | I, No | E, Sp | P | 1 | Fo | A | Pv |
| 10 | 40 | F | UE | +11p, 18qLOH | NE | NE | Y | N | Fa | P | I | E, Sp | Fo | 0 | Fo | A | Pv |
| 11 | 22 | F | LE | +11p | R | Pl | Y | N | Ns, SC | A | I | E | A | 0 | Fo | A | Pv |
| 12 | 75 | F | UE | +11p | F | Pl | Y | Y | Fa, SC | Mi | I | E, Sp | A | 0 | Fo | Mi | Pv |
| 13 | 28 | F | LE | +11p | R | W | Y | N | S | Mi | I | E, Sp | Fo | 1 | Fo | A | Pv |
| 14 | 61 | M | UE | +11 p | R | NE | Y | N | Ns, Fa | Mi | NE | E, Sp | A | 1 | Fo | Mi | Pv |
| 15 | 28 | F | Nose | +11p | R | W | Y | N | Fa, SC | A | I | E, Sp | Fo | 0 | N | Mi | Pv |
| 16 | 25 | F | UE | +11p | Fl | W | Y | N | Fa, SC | Mi | I | E, Sp | Fo | 0 | N | Mi | Pv |
| 17 | 40 | M | UE | +11p | Fl | Pl | Y | N | Ns, SC | Mi | I | E, Sp | Fo | 0 | Fo | A | Pv |
| 18 | 14 | F | Cheek | +11p | R | W | Y | N | Ns, Fa | Mi | I | E, Sp | P | 0 | Fo | A | Pv |
| 19 | 72 | F | Back | +11p | Fl | Pl | Y | N | Fa, SC | Mi | I | E, Sp | A | 0 | N | A | Pv |
| 20 | 10 | M | Flank | +11p, +8p | R | W | Y | N | Fa, SC | P | I | E, Sp | P | 2 | Fo | A | Pv |
| 21 | 45 | F | UE | +11p | R | W | Y | N | Ns, SC | Mi | I | E, Sp | Fo | 0 | Fo | A | Pv |
| 22 | 33 | F | UE | +11p | R | W | Y | Y | Ns, SC | P | I | E, Sp | Fo | 1 | N | A | Pv |
| 23 | 37 | M | LE | +11p | R | W | Y | N | S, Fa | Mi | I | E, Sp | P | 0 | Fo | A | BL |
| 24 | 30 | F | Back | +11p | R | W | Y | N | Ns, Fa | Mi | I | E, Sp | Fo | 1 | Fo | A | Pv |
| 25 | 30 | M | LE | +11p | NE | NE | Y | N | Ns, Fa | A | I | E, Sp | Fo | 1 | Fo | NE | In |
| 26 | 56 | M | LE | +11p | R | W | Y | N | Ns, Fa | A | I | E, Sp | Fo | 0 | Fo | A | Pv |
| 27 | 7 | M | Nose | +11p | R | NE | Y | N | Ns, Fa | P | NE | E, Sp | P | 0 | Fo | NE | Pv |
| 28 | 41 | F | Nose | +11p | NE | NE | Y | N | Ns, Fa | Mi | NE | E, Sp | Fo | 1 | Fo | NE | Pv |
| 29 | 16 | F | Face | (**) | R | W | Y | N | Ns, Fa | P | I | E, Sp | P | 0 | N | A | Pv |
| 30 | 57 | M | Nose | (***) | NE | W | Y | Y | Fa, SC | P | I | E, Sp | Fo | 0 | N | Mo | Pv |
| 31 | 8 | F | Cheek | +11p, −6p, −9, 18pq, 19pLOH | R | W | Y | N | S | A | I, No | E, Sp | P | 3 | Fo | A | In |
| 32 | 28 | F | Cheek | (**) | NE | W | Y | N | Fa, SC | Mi | I | E, Sp | Fo | 1 | N | Mi | Pv |
| 33 | 33 | F | LE | +11p, +7q | NE | NE | Y | N | Ns, Fa | Mi | NE | E, Sp | A | 2 | N | NE | Pv |
| 34 | 18 | F | Eyebrow | +11p | R | W | Y | N | Ns, Fa | P | I | E, Sp | Fo | 1 | Fo | A | Pv |
| 35 | 19 | F | Nose | +11p, +7q | R | W | Y | N | Ns, Fa | Mi | I | E, Sp | P | 1 | N | A | Pv |
| 36 | 19 | F | Forehead | +11p | R | W | Y | N | Fa, SC | P | I | E, Sp | A | 0 | Fo | A | Pv |
| 37 | 59 | M | Cheek | (**) | NE | NE | Y | N | Fa, SC | Mi | NE | E, Sp | Fo | 0 | N | Mo | Pv |
| 38 | 66 | F | LE | +11p | Fl | Pl | Y | N | Fa, SC | Mi | I | E, Sp | A | 0 | Fo | A | Pv |
| 39 | 42 | F | UE | +11p, −9, 13pLOH | R | W | Y | N | Ns, Fa | Mi | I | E, Sp | A | 1 | Fo | A | Pv |
| 40 | 14 | M | Back | +11p, −9 | R | W | Y | N | Fa, SC | A | I | E, Sp | A | 3 | Fo | A | Pv |
Paucicel= paucicellular, Cytomorph= cytomorphology, Multinucl= multinucleation, Mit= dermal mitoses per mm2, Pigmt= pigment, Solar elast= solar elastosis, Inflam= inflammation, F= female, M= male, UE= upper extremity, LE= lower extremity, R=raised, Pa=papillomatous Fl=flat, NE= not evaluable, W=wedge-shaped, Pl= plaque-like, Y= yes, N= no, S= sheet-like, Ns= nests, Fa= short fascicles or strands, SC= single cells, Mi= mild, P= prominent, A= absent, I=infiltrative, No= nodular/bulbous, E= epithelioid, Sp= spindle, Mo=moderate, Pv=perivascular, In=interstitial, It= intermediate, Fo=focal, BL = band-like
SNP or CGH array was performed except where specified: (**) 11p gains detected by FISH and melanoma FISH assay performed, or (***) where only FISH for 11p was performed and detected gains